In vivo test systems

• Muscular disorders - Sarcopenia (spontaneous (aging), immobilization, nephrectomy, paralytic substance)
   – mouse and rat

• Bone disorders such as Critical bone defect (NU), Non-critical bone defect, Osteotomy, Fracture, osteoporosis (surgically induced)
   – mouse, rat, dog, sheep, rabbit

• Joint disorders - Osteoarthritis  (spontaneous, chemically or surgically induced)-   
   – mouse, rat, dog, sheep, minipig   

• Gastrointestinal disorders ( inflammatory bowel disease, dysbiosis)
   – mouse and rat

• Inflammatory disorders – Arthritis, Rheumatoid arthritis (Collagen Induced)
   – mouse and rat

• Healthy models
   – all species


TYPE OF STUDIES

• Pharmacodynamics, pharmacokinetics, dose range finding, proof-of-concept studies

• Acute and systemic toxicity studies (sub-acute, sub-chronic, and chronic)

• Local effects studies (irritation, sensitization, local Tolerance)

• Safety Pharmacology studies

• Parmacokinetics/Toxicokinetics/Bioavailability/Biodistribution studies