Biomarker Portfolio
We offer a comprehensive portfolio of validated biomarkers that can be used to support your development program. These biomarkers have been tested and proven to be reliable indicators. Our portfolio can save you time and resources by providing a selection of well-characterized options for your research.
Validated human biomarkers
Inflammatory & Immune Markers
- AGEs (Advanced Glycation End Products): Non-enzymatic glycation products formed by the reaction of reducing sugars with proteins, lipids, or nucleic acids. Often associated with chronic diseases like diabetes and atherosclerosis.
- IFN-γ (Interferon-gamma): A cytokine involved in immune response, inflammation, and antiviral activity. Elevated levels are often associated with chronic inflammation.
- IL-1β (Interleukin-1 beta): A pro-inflammatory cytokine involved in a wide range of inflammatory responses.
- IL-2 (Interleukin-2): A cytokine primarily involved in T cell proliferation and differentiation.
- IL-4 (Interleukin-4): A cytokine associated with allergic and anti-inflammatory responses.
- IL-6 (Interleukin-6): A cytokine involved in inflammation and immune response. Elevated levels are associated with various inflammatory conditions.
- IL-8 (Interleukin-8): A cytokine involved in neutrophil recruitment and activation, often elevated in inflammatory conditions.
- IL-10 (Interleukin-10): An anti-inflammatory cytokine involved in regulating immune response.
- IL-12p70 (Interleukin-12): A cytokine involved in the differentiation of T helper cells and natural killer cell activation.
- IL-13 (Interleukin-13): A cytokine involved in allergic inflammation and fibrosis.
- TNF-α (Tumor Necrosis Factor-alpha): A pro-inflammatory cytokine involved in a wide range of inflammatory and immune responses.
Bone and Cartilage Markers
- Aggrecan: A major proteoglycan component of cartilage. Used as a biomarker for cartilage degradation.
- COMP (Cartilage Oligomeric Matrix Protein): A protein found in cartilage and bone. Elevated levels may indicate cartilage damage.
- CTX-1 (C-telopeptide of type I collagen): A biomarker for bone resorption.
- CTX-2 (C-telopeptide of type II collagen): A biomarker for cartilage degradation.
- Coll2-1 (Collagen II): A component of cartilage. Used as a marker of cartilage metabolism.
- Coll2-1 NO2 (Nitrotyrosine Collagen II): A modified form of collagen II associated with oxidative stress and inflammation in cartilage.
- HA (Hyaluronic Acid): A glycosaminoglycan found in extracellular matrix. Used as a marker of tissue hydration and inflammation.
- MMP-1 (Matrix Metalloproteinase-1): An enzyme involved in collagen degradation. Elevated levels are associated with tissue breakdown.
- MMP-3 (Matrix Metalloproteinase-3): An enzyme involved in extracellular matrix degradation.
- MMP-9 (Matrix Metalloproteinase-9): An enzyme involved in extracellular matrix degradation, often associated with inflammation.
- MPO (Myeloperoxidase): An enzyme released by neutrophils, involved in oxidative stress and inflammation.
- NTx (N-telopeptide of type I collagen): A biomarker for bone resorption.
- Ostease BAP (Bone-specific Alkaline Phosphatase): An enzyme involved in bone formation.
- Osteocalcin: A bone-specific protein involved in bone mineralization.
- PIIANP (Picolinic Acid-stabilized Amino-terminal Propeptide of Type I Collagen): A biomarker for bone formation.
- TGFβ1,2,3 – (Transforming Growth Factor beta): A group of cytokines involved in cell growth, differentiation, and tissue repair.
Other Markers
- CS-846: measures newly formed aggrecan.
- PGE2: A lipid mediator involved in inflammation and pain.
- TRAcP 5b: An enzyme associated with osteoclast activity and bone resorption.
Biomarkers validated in other species
Inflammatory & Immune Markers
- GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor): A cytokine involved in the production of white blood cells.
- IFN-γ (Interferon-gamma): A cytokine involved in immune response, inflammation, and antiviral activity.
- IL-1β (Interleukin-1 beta): A pro-inflammatory cytokine involved in a wide range of inflammatory responses.
- IL-2 (Interleukin-2): A cytokine primarily involved in T cell proliferation and differentiation.
- IL-4 (Interleukin-4): A cytokine associated with allergic and anti-inflammatory responses.
- IL-5 (Interleukin-5): A cytokine involved in the growth and differentiation of eosinophils.
- IL-6 (Interleukin-6): A cytokine involved in inflammation and immune response.
- IL-7 (Interleukin-7): A cytokine involved in the development of T cells.
- IL-8 (Interleukin-8): A cytokine involved in neutrophil recruitment and activation.
- IL-10 (Interleukin-10): An anti-inflammatory cytokine involved in regulating immune response.
- IL-12p70 (Interleukin-12): A cytokine involved in the differentiation of T helper cells and natural killer cell activation.
- IL-13 (Interleukin-13): A cytokine involved in allergic inflammation and fibrosis.
- IL-15 (Interleukin-15): A cytokine involved in the activation and proliferation of natural killer cells and T cells.
- IL-18 (Interleukin-18): A cytokine involved in inflammation and immune response.
- IP-10 (Interferon-gamma Inducible Protein-10): A chemokine involved in inflammation and immune response.
- KC/GRO (Keratinocyte-derived Chemokine/Growth-Related Oncogene): A chemokine involved in inflammation and neutrophil recruitment.
- MCP-1 (Monocyte Chemoattractant Protein-1): A chemokine involved in the recruitment of monocytes and other inflammatory cells.
- TNF-α (Tumor Necrosis Factor-alpha): A pro-inflammatory cytokine involved in a wide range of inflammatory and immune responses.
Bone and Cartilage Markers
- COMP (Cartilage Oligomeric Matrix Protein): A protein found in cartilage and bone.
- CTX-1 (C-telopeptide of type I collagen): A biomarker for bone resorption.
- CTX-2 (C-telopeptide of type II collagen): A biomarker for cartilage degradation.
- MMP1 (Matrix Metalloproteinase-1): An enzyme involved in collagen degradation.
- MMP13 (Matrix Metalloproteinase-13): An enzyme involved in collagen degradation.
- Osteocalcin: A bone-specific protein involved in bone mineralization.
- PIIANP (Picolinic Acid-stabilized Amino-terminal Propeptide of Type I Collagen): A biomarker for bone formation.
Other Markers
- CS-846: measures newly formed aggrecan.
- PGE2: A lipid mediator involved in inflammation and pain.
- VEGF-A: A growth factor involved in angiogenesis.
- Creatinine: Used to assess kidney function and to normalize measurements in urine.
- Urea: A waste product produced by protein metabolism. Used to assess kidney function and to normalize measurements in synovial fluid.
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