Mitochondrial haplogroups define two phenotypes of osteoarthritis.

Published on 11/05/2012

Mitochondrial haplogroups and OA phenotypes

The mitochondrial DNA haplogroups are potential complementary candidates for biomarkers of OA.

Serum levels of OA-related biomarkers were analyzed in 48 OA patients and 52 healthy controls carrying the haplogroups H and J. MMP-13 was the only biomarker significantly increased in OA patients compared to healthy controls in both haplogroups H and J. The collagen type II biomarkers, Coll2-1, Coll2-1NO(2), the Coll2-1NO(2)/Coll2-1 ratio, C2C, CPII, and the C2C:CPII ratio were significantly increased in OA patients carrying haplogroup H compared to OA carriers of the haplogroup J



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