Decrease of Coll2-1 and Coll2-1 NO2 by HA IA injections

Early Decrease of Serum Biomarkers of Type II Collagen Degradation (Coll2-1) and Joint Inflammation (Coll2-1 NO2) by Hyaluronic Acid Intra-Articular Injections in Patients With Knee Osteoarthritis:A Research Study Part of the Biovisco Study
To measure the evolution of the serum levels of specific Osteoarthritis (OA) biomarker, Coll2-1 and Coll2-1 NO2 in knee osteoarthritic patients after viscosupplementation (VS). Fifty-one patients with unilateral symptomatic knee were recruited for this prospective open label study. They received three intra-articular injections of 2 ml of hyaluronic acid (Hylan GF-20) and were followed for 3 months. The serum concentrations of Coll2-1 and Coll2-1 NO2 were significantly higher in KL III/IV patients compared to KL I/II patients at baseline and decreased systematically over time after VS.