Coll2-1 increased in primary guinea pig knee osteoarthritis

Collagen fibril disruption occurs early in primary guinea pig knee osteoarthritis, only serum Coll2-1 increased
Collagen fibril disruption and expression of the collagenase-generated cleavage neoepitope, 9A4, were observed as early as 2 months of age, despite the appearance of histological OA at 4 months of age. Only serum Coll2-1 increased coincident with the early disruption of the collagen fibril between 3 weeks and 7 months.